Do thiazolidine compounds act on intracellular amastigotes of Trypanosoma cruzi? A systematic review

Benznidazole (Bdz) are the drug of choice to treat Chagas Disease. However, causes several side effects, and Trypanosoma cruzi, etiological agent disease, can be less susceptible action drugs in chronic phase, due its reduced metabolism dormancy tissues. Thus, using compounds that lethal amastigote forms, which prevalent disease is essential for success therapy. We propose evaluate, though a systematic review, efficacy thiazolidine imidazolidine derivatives against T. cruzi intracellular amastigotes, compare results with those Bdz, A search was made on eight English Language Systematic Databases - Science Direct, Scopus, Pubmed, Google Scholar, LILACS, Scielo, Trip Database Cochrane, collect studies, without time scale. IC50 values, cytotoxic effects (CC50), selective index (SI), mechanism each compound length treatment included this review evaluate effectiveness compound. The 2-Iminothiazolidin-4-one 18 more effective than as it affected amastigotes by making structural modification parasite, inhibiting cruzain, being promising antichagasic